Liposarcoma in Panama
What is liposarcoma?
Liposarcoma is a type of cancer that originates in the body’s fatty tissues, specifically fat cells.
It is classified as a soft tissue sarcoma, which are malignant tumors that develop in the body’s connective tissues.
Liposarcoma is characterized by the uncontrolled proliferation of malignant fat cells in different parts of the body, including: the thighs, abdomen, arms, legs, and other deep tissues.
Types of liposarcoma
There are several subtypes of liposarcoma, which have distinctive features in terms of their microscopic appearance and clinical behavior.
Among them we can mention:
Well-differentiated liposarcoma
This type of liposarcoma is distinguished by having mature, well-differentiated fat cells. It is less aggressive and has a better prognosis compared to other subtypes of liposarcoma.
Myxoid liposarcoma
Myxoid liposarcoma is made up of immature fat cells mixed with connective tissue, tends to grow slowly, and may have cystic or jelly-like areas in the tumor.
Pleomorphic liposarcoma
It is composed of mature fat cells and malignant cells of anaplastic or pleomorphic appearance. It is more aggressive than well-differentiated liposarcoma and can be difficult to treat.
Dedifferentiated liposarcoma
Dedifferentiated liposarcoma is a more aggressive form of liposarcoma that is characterized by the presence of undifferentiated or non-lipogenic areas in the tumor. It can also manifest features of other subtypes of liposarcoma.
Symptoms of liposarcoma
Symptoms of liposarcoma can vary depending on the location, type, and size of the tumor.
Some of the symptoms commonly associated with liposarcoma include:
- Abdominal pain.
- Abdominal swelling.
- Rapid feeling of fullness when eating.
- Constipation.
- Blood in the stool.
- Fatigue.
- Changes in the skin over the affected area.
Causes of Liposarcoma
Although the exact causes of liposarcoma are not known, some risk factors have been identified that may increase the likelihood of developing this disease.
Risk factors include:
Genetics
Some people may have an inherited genetic predisposition that increases their risk of developing liposarcoma.
Radiation
Prior exposure to radiation, whether from previous medical treatments or from occupational or environmental exposure, has been associated with an increased risk of liposarcoma.
Exposure to toxic chemicals
A possible association has been observed between exposure to certain toxic chemicals, such as vinyl chloride used in the plastics industry, in the development of liposarcoma.
Diagnostic process
The diagnosis of liposarcoma is usually based on a combination of different medical tests and evaluations, starting with a physical exam to evaluate any palpable mass or tumor in the body; and continuing with imaging tests such as X-rays, magnetic resonance imaging (MRI), and computed tomography (CT) scans, to visualize the size, location, and characteristics of the liposarcoma.
In most cases, biopsy is a key test to confirm the diagnosis of liposarcoma.
In this, a sample of tissue from the tumor is extracted for analysis in the laboratory; The pathological analysis will be used to determine if cancer cells are present and to classify the type of liposarcoma.




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Treatments for liposarcoma
Treatment of liposarcoma usually involves a combination of conservative and/or surgical approaches.
Here are some of the treatments used for liposarcoma:
Surgery
Surgery is the main treatment for liposarcoma and aims to completely remove the tumor. In some cases, a wide resection involving the removal of surrounding healthy tissue may be necessary to ensure complete removal of the cancer.
Radiotherapy
Radiation therapy uses high-energy beams to kill cancer cells or shrink them before or after surgery.
Chemotherapy
Although liposarcoma usually does not respond well to chemotherapy, in some cases it can be used to control the growth of recurrent or disseminated tumors.
Targeted therapy
In selected cases of liposarcoma, targeted therapy drugs that target specific changes in cancer cells may be used to inhibit their growth and spread. It is important to mention that the treatment of liposarcoma must be individualized and adapted to the specific needs of each patient according to their needs.