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Roberto García

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What is Adrenal Cancer?

Anatomically, the adrenal glands are located above the kidneys (one in each organ). Its main function is to produce hormones that control heart rate, blood pressure, and other important functions for the body.

Adrenal cancer that begins on the outside of the adrenal glands is known as Adrenocortical Carcinoma, while if it develops on the inside of the gland, it is called Malignant Pheochromocytoma.

Although most tumors that appear in the adrenal glands are benign (adenomas); These are often detected accidentally during a study and can remain unchanged, without manifesting symptoms, or representing a real problem for the patient.

¿Qué es el Cáncer Suprarrenal

Symptoms

During the development of adrenal cancer , one or more of the following symptoms may occur:

Loss of appetite (loss of appetite)

Sudden changes in weight (it can be loss or gain with fat accumulation in the neck and shoulders.

Nausea and vomiting

Muscle and bone weakness

Changes in blood pressure

Back pain

Abdominal swelling

Hormonal uncontrol

Diagnosis

As soon as adrenal cancer is suspected, several tests should be started to help determine its diagnosis with certainty.

Blood and urine tests

In order to detect alterations in the concentration of substances such as cortisol, androgens or aldosterone (produced by the adrenal gland); The specialist orders a series of laboratory tests.

Diagnostic imaging

Magnetic resonance imaging, positron emission tomography or computed tomography; These are some of the tests that are requested to visualize the growth of the adrenal glands due to tumor formation.

Laboratory study of the adrenal gland

When there is a suspicion that the patient suffers from adrenal cancer and the specialist removes the gland; The sample is sent to a pathologist to determine what type of cells are involved (biopsy).

Treatments for Pancreatic Cancer

Once the diagnosis of adrenal cancer is confirmed, the main procedure used is surgery.

However, there are other treatments that prevent growth, the recurrence of the tumor or help control symptoms, when surgery is not an option. Among these we have the following:

Surgery

Surgery to remove the adrenal glands is called adrenalectomy. Depending on the case, it can be done alone or bilaterally; in which case the patient will need to cover the hormone supply with medication. This surgery may be done even when the cancer has not developed from the glands themselves, but has spread to affect them. In any case, the technique can be traditional (open surgery) or minimally invasive (laparoscopic), a procedure that is also applied to certain non-cancerous tumors that grow too large or cause alterations in the patient. Likewise, if during the execution of the surgery it is seen that the cancer has spread to the liver or kidney, the usual thing would be to remove that part of the organ or all of it at the time.

Medication to prevent recurrence

After surgery, the consumption of Mitotane is indicated to delay the recurrence of this condition. This drug is given to patients at high risk of recurrence; however, some research is ongoing to confirm the effectiveness of this drug.

Chemotherapy

In the presence of adrenal cancer that cannot be removed, a scheme that combines various chemicals is usually started to help destroy cancer cells and thus slow the progression of the cancer.

Radiation therapy

This treatment applies high-powered x-rays to destroy cancer cells and may be combined with chemotherapy based on medical judgment. In addition, radiotherapy also helps to reduce pain and other symptoms caused by cancer, so it is also usually administered for this purpose.

Preparing for Surgery

Before entering the operating room to perform an adrenalectomy, several preoperative studies must be done; among them, an assessment by the anesthesiologist.

Among the recommendations to patients with cancer before and even after surgery, the following are indicated:

Learn about your type of cancer and all available treatment options.

Learn about your type of cancer and all available treatment options.

Keep family or friends close who can be your emotional and practical support, before and after any treatment.

If you have a smoking habit, avoid it for a few days before surgery to avoid complications when it comes to anesthetic management.

Practice some moderate-intensity exercise, such as walking for 50 to 60 minutes a day (unless there is a medical contraindication).

Revision by an endocrinologist is critical to monitor adrenal gland function and facilitates better management of vital functions during the procedure.

Know the type of food and drinks you should consume, as well as the most convenient time to do so. You should also consider stopping supplements and medications, unless there is prior control of these by the treating doctor.

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Causes of Adrenal Cancer

Some studies reveal that there is no specific cause that predisposes the development of cancer in the adrenal glands. However, there are several risk factors that must be considered.

In particular, age is one of them, as there is a certain prevalence in young children (under 5 years of age) and in adults between 40 and 50 years of age.

Although cell mutation is the main cause of this type of cancer, it is not known exactly what causes it.

In turn, other hereditary risk factors are added, based on syndromes that pass from generation to generation, among which we have:

  • Lynch syndrome
  • Carney Complex
  • Li-Fraumeni syndrome
  • Multiple endocrine neoplasia type 1
  • Beckwith-Wiedemann syndrome
Causas del cáncer suprarrenal

Importance of Early Detection of Adrenal Cancer

When Adrenal Cancer Screening occurs during the initial stage, the chances of cure of the patient are greater. Conversely, if the cancer has already spread to other parts of the body, the chances decrease.

Similarly, as we have already mentioned, most tumors in the adrenal glands are benign; so it is important to analyze any evidence that exists to proceed accordingly.

Stages of Adrenal Cancer

Each stage of cancer involves a degree of complication, but it is also necessary to identify and apply the specific treatment that provides the greatest benefit to the patient.

Stage I

In this initial stage we will find a tumor that measures less than 5 cm, without spread outside the adrenal gland. In these patients, no spread to regional lymph nodes is observed.

Stage II

Then there are tumors in which a small development is observed. Although there is an increase in size (greater than 5 cm), there is no spread outside the adrenal gland to regional lymph nodes or nearby organs.

Stage III

Tumor growth begins to be observed on a larger scale, with spread to 3 or 4 regional lymph nodes. At this point, there is already evidence of a spread in distant organs such as the spleen, kidney, diaphragm, pancreas and liver.

Stage IV

In this last stage, the tumor spreads to other parts of the body (metastasis). The primary tumor is called non-assessable and the metastasis monopolizes the large blood system such as the vena cava and renal vein.

How to prevent adrenal cancer?

Despite the many studies carried out in this area, unfortunately there is currently no specific way to prevent cancer of the adrenal glands.

In fact, among the actions that could be taken into account to act early, it is extremely important to go to the doctor in case of discomfort (any of the symptoms present) or to observe a suspicious image casually in imaging studies.

Frequently Asked Questions

In these answers you can expand your knowledge of the topic and share information with those who may need it.

The stage in which the decay of all body functions is evident due to metastasis is stage IV.

There are a large number of mutations, which can be hereditary or acquired.

Even so, the development of adrenal cancer does not have any scientific evidence to confirm the existence of a hereditary pattern, although there is some association with some hereditary syndromes.

Adrenal cancer has a high malignant potential that offers a very low prognosis of life.

Therefore, it usually spreads at a distance in a short time; metastasizing to the liver, kidneys, lungs, and large blood system (renal vein and vena cava).

Finally, this dissemination occurs in about 82% of cases, which translates into a median survival of 15 months.

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